Chinese Journal of Dental Research

Chin J Dent Res
CN 10-1194/R . ISSN 1462-6446 . eISSN 1867-5646 . Quarterly

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Chin J Dent Res 2024;27(1):39–46; doi:10.3290/j.cjdr.b5136729

Characteristic and Import Mechanism of Protein Nuclear Translocation

Writer:Zi Yan SUN, Zhi Peng FAN Clicked:

Objective: To investigate the current status and distribution of resources for oral health in China, by means of analysing national data from the National Investigation of Resources for Oral Health. Methods: The National Investigation of Resources for Oral Health in China was performed in 2015, in parallel with the 4th National Oral Health Survey of China (2015 to 2016). A structured questionnaire on resources for oral health was used to collect the data of professional institutions and stomatological/dental workforce in each province. For each province, the Health Commission was responsible to summarise the status and distribution of institutions with stomatological/dental departments and stomatological/dental workforce within the administration of its authority. Descriptive analysis of resources for oral health was performed to learn about the number and percentage of each category both for each province and nationally. The ratio of number of stomatological/dental workforce to population was also calculated

Coordination and information exchange among the various organelles ensure the precise and orderly functioning of eukaryotic cells. Interaction between the cytoplasm and nucleoplasm is crucial for many physiological processes. Macromolecular protein transport into the nucleus requires assistance from the nuclear transport system. These proteins typically contain a nuclear localisation sequence that guides them to enter the nucleus. Understanding the mechanism of nuclear import of macromolecular proteins is important for comprehending cellular processes. Investigation of disease-related alterations can facilitate the development of novel therapeutic strategies and provide additional evidence for clinical trials. This review provides an overview of the proteins involved in nuclear transport and the mechanisms underlying macromolecular
protein transport.

Keywords: karyopherin, nuclear import, nuclear localisation sequence, nuclear pore complex, nucleocytoplasmic transport
(editor:CJDR)