Chin J Dent Res 2025;28(3):163–172; doi:10.3290/j.cjdr.b6553419
Biomimetic Mineralisation – Nature-inspired Strategy for Promising Hard Tissue Regenerative Materials Development
Writer:Lin Xue ZHANG, Zuo Ying YUAN, Yu Ming ZHAO, Yun Fan ZHANG Clicked:
Objective: To investigate the oral health status and related factors of 12-year-olds from regions with and without coverage of the National Oral Health Comprehensive Intervention Program in China by means of analysing national data from the 4th National Oral Health Survey. Methods: Data of 12-year-olds participating in the 4th National Oral Health Survey of China were used for statistical analysis. Children who were recruited in the survey completed a dental examination and filled in a questionnaire. Oral health status, pit-and-fissure sealant history, oral hygiene behaviours, sugar consumption habits, status of dental service utilisation, and oral health knowledge were compared between children from regions with and without coverage of the national programme. For the number of decayed, missing and filled permanent teeth (DMFT) and its components, as well as the number of teeth with pit-and-fissure sealants, mean values were statistically tested to see if significance existed between regions covered by the nat
Biomineralisation is a remarkable biological process in which living organisms exert precise control over the nucleation and growth of inorganic crystalline phases, resulting in the formation of hierarchically structured biocomposites that exhibit exceptional mechanical and functional properties. Since damage to bone and teeth directly affect everyday life, various biomimetic mineralised materials have been engineered for use in biomedical applications. While bioinspired materials typically demonstrate superior mechanical properties and biological functions, significant disparities remain between biomimetic constructs and their natural counterparts, especially concerning mechanical performance and multiscale structural organisation. This review initially describes the dynamic reciprocity between type I collagen fibrils, amorphous calcium phosphate phases and multifunctional non-collagenous protein within mineralisation microenvironments. Furthermore, it evaluates recent progress in advanced biomaterials based on biomimetic mineralisation strategies and seeks to spark innovative and promising solutions for investigators exploring biomineralisation principles in regenerative medicine and hard tissue reconstruction. Existing problems and future directions are discussed.
Keywords: biomineralisation, calcium phosphate, calcium, hard tissue regeneration, noncollagenous proteins
(editor:CJDR) |