Mar 22,2022
Microspheres have been widely utilised as versatile carriers in biomedical applications. In recent years, as a new type of injectable scaffold, microspheres have attracted increasing attention in the field of regenerative medicine owing to their various advantages including their small size, large specific surface area and mimicry of the 3D native environment. These characteristics enable them to adopt the narrow and irregular anatomy of the tooth and
become an ideal scaffold for endodontic regeneration. Microspheres play an important role in carrying biologics (cells, biomolecules and drugs), which effectively regulate the fate of stem cells and control the release of growth factors and drugs. Cell-laden microspheres, which can be divided into microcarriers and microcapsules, have great application prospects in dental pulp regeneration. This paper summarises the properties and characteristics of microsphere scaffolds used in tissue engineering, placing emphasis on their advantages and applications in endodontic regeneration.
Key words: dental pulp, endodontic regeneration, microcapsules, microcarriers, microspheresRead More
Mar 22,2022
Extensive research has indicated that high glucose levels play an important role in cancer. A high glycaemic index, glycaemic load diet, high sugar intake, high blood glucose and diabetes mellitus all increase the risk of cancer. Various signals are involved in high glucose–induced tumorigenesis, cancer proliferation, apoptosis, invasion and multidrug resistance. Reactive oxygen species might be important targets in cancer progression that are induced by high glucose levels. Drugs such as metformin and resveratrol may inhibit high glucose–induced cancer. As the impact of high glucose levels on cancer progression and therapy is a novel finding, further research is required.
Key words: cancer, high glucose, progression, therapy, tumorigenesis
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Feb 05,2021
The newly emerged coronavirus disease (COVID-19) is a respiratory disease caused by a novel coronavirus (2019-nCoV) which was first identified in China in December 2019. It is a highly contagious infection that can spread from person to person through close contact and respiratory droplets. The healthcare personnel of the Department of Oral and Maxillofacial Surgery are especially vulnerable to the infection due to their extensive and close exposure to patients’ oral and nasal cavities and secretions. As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic.
Key words: diagnosis and treatment process, new coronavirus, oral and maxillofacial surgery, protection
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Feb 05,2021
At present, various antibacterial therapeutic modalities are available in the clinic. However, due to the rampant abuse of antibiotics over the past few decades and the consequent emergence of innumerable drug-resistant strains of bacteria, it is imperative to develop new and effective antibacterial therapeutic strategies. In recent years, the physical stimuli–based approach to antibacterial therapy has aroused much interest as an alternative to antibiotics and has become a major focus of antibacterial research. In this review, the application of different physical stimuli, including electricity, magnetism, light, ultrasound and thermal stimulation, in antibacterial research is critically examined in order to provide new ideas and directions for the further development of antibacterial therapy in clinical dentistry.
Key words: acoustics, electricity, magnetism, photodynamics, physical stimulation, research progress, thermal
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Aug 21,2017
Clarivate Analytics is launching the Emerging Sources Citation Index (ESCI), which will extend the universe of publications in Web of Science to include high-quality, peer-reviewed publications of regional importance and in emerging scientific fields. ESCI will also make content important to funders, key opinion leaders, and evaluators visible in Web of Science Core Collection even if it has not yet demonstrated citation impact on an international audience. Journals in ESCI have passed an initial editorial evaluation and can continue to be considered for inclusion in products such as SCIE, SSCI, and AHCI, which have rigorous evaluation processes and selection criteria. All ESCI journals will be indexed according to the same data standards, including cover-to-cover indexing, cited reference indexing, subject category assignment, and indexing all authors and addresses.
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4 February 2022, the “start of spring” day, the first of the 24 solar terms of the year and also part of the Chinese New Year festival, marked the opening of the XXIV Winter Olympic Games (Beijing 2022). Beijing is now the first city to have hosted both the Summer and Winter Olympics and Paralympics. These events are great opportunities for athletes and sports fans from all over the world to meet. We hope the pandemic will end soon, that the world will return to normal, and that we will work “together for a shared future”.
For our journal, with great support and cooperation from Berlin, London and Beijing, we have continued to work smoothly over the past year. We have welcomed 14 new members, who are renowned international scholars, to our editorial board. We would like to thank them for their support and contribution!
In this issue, I would like to recommend several articles. The first of these is “Emerging role of high glucose levels in cancer progression and therapy” contributed by Dr Cai et al, members of Prof Tie Jun Li’s team from Peking University School of Stomatology. The article offers a comprehensive review of this broad topic. Extensive research has indicated that high glucose plays an important role in the development and progression of cancer. As a novel finding in cancer progression and therapy, high glucose needs to be studied further, and I think this article may offer a new perspective for readers who work in cancer research.
There are also two other reviews. The first of these is “Exploration of genetic variants of non-syndromic cleft lip with or without palate and underlying mechanisms” by Prof Lin Wang’s team at the Affiliated Hospital of Stomatology, Nanjing Medical University. They performed functional studies on related loci and genes by using molecular biology, cell biology, animal models and other methods, which provide a basis for the construction of the NSCL/P genetic map in the Chinese population and help to implement individualized prophylaxis and treatment. The second is contributed by Prof Tian’s group at the West China Hospital of Stomatology, Sichuan University, entitled “Microspheres and their potential in endodontic regeneration application”, which summarises the properties and characteristics of microsphere scaffold used in tissue engineering, placing emphasis on their advantages and applications in endodontic regeneration.
The systematic review on “Accuracy of mandibular reconstruction with a vascularised Iliac flap using 3D templates” and systematic review and meta-analysis “Relationship between presence of third molars and prevalence of periodontal pathology of adjacent second molars”, from Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, and School of Stomatology, Fourth Military Medical University, respectively, are sure to be helpful to clinicians in their practice. There is also a research article on “Near infrared laser photobiomodulation of periodontal ligament stem cells” from the School of Dentistry, Hamadan University of Medical Sciences, Iran, and a case report on “Management of separated instruments extruded into the maxillary sinus and soft tissue” from the School of Stomatology, Capital Medical University, China that are worthy of your attention.
I wish you a very happy, healthy and successful new year!
Prof Guang-yan Yu
Editor-in-chief
Salivary adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) are the most common types of salivary gland tumours; the former is malignant and the latter is benign but with features of a border tumour. Proteoglycans (PGs) produced by neoplastic myoepithelial cells are ubiquitous in both types of tumours. However, normal myoepithelial cells of salivary glands do not have the ability to secrete PGs. When the synthesis of PGs is blocked, the pulmonary metastasis and perineural growth of salivary ACC as well as the implanting growth of salivary PA are inhibited, highlighting the important functions of PGs in the tumourigenesis and development of these two tumours. In this review, we summarise literature from the past 40 years, including more recent findings from our laboratory, to clarify the pivotal roles of PGs produced by neoplastic myoepithelial cells in both the histogenesis and biological behaviours of ACC and PA.
Key words: adenoid cystic carcinoma, pleomorphic adenoma, proteoglycans, RNA interference, xylosyltransferases